Nos publications scientifiques

Retrouvez l’Institut ANALGESIA dans les publications des équipes de notre réseau soin/recherche,
toujours à la pointe de l’innovation dans le domaine de la douleur !

eDOL mHealth App and Web Platform for Self-monitoring and Medical Follow-up of Patients With Chronic Pain: Observational Feasibility Study

Nicolas Kerckhove, Noémie Delage, Sébastien Cambier, Nathalie Cantagrel, Eric Serra, Fabienne Marcaillou, Caroline Maindet, Pascale Picard, Gaelle Martiné, Rodrigue Deleens, Anne-Priscille Trouvin, Lauriane Fourel, Gaelle Espagne-Dubreuilh, Ludovic Douay, Stéphane Foulon, Bénédicte Dufraisse, Christian Gov, Eric Viel, François Jedryka, Sophie Pouplin, Cécile Lestrade, Emmanuel Combe, Serge Perrot, Dominique Perocheau, Valentine De Brisson, Pascale Vergne-Salle, Patrick Mertens, Bruno Pereira, Abdoul Jalil Djiberou Mahamadou, Violaine Antoine, Alice Corteval, Alain Eschalier, Christian Dualé, Nadine Attal, Nicolas Authier. Publiée le 02 mars 2022 dans le JMIR

Colorectal Cancer Survivors Suffering From Sensory Chemotherapy-Induced Peripheral Neuropathy Are Not a Homogenous Group: Secondary Analysis of Patients’ Profiles With Oxaliplatin-Induced Peripheral Neuropathy

Nicolas Kerckhove, Marie Selvy, Céline Lambert, Coralie Gonneau, Gabrielle Feydel, Caroline Pétorin, Agnès Vimal-Baguet, Sergey Melnikov, Sharif Kullab, Mohamed Hebbar, Olivier Bouché, Florian Slimano, Vincent Bourgeois, Valérie Lebrun-Ly, Frédéric Thuillier, Thibault Mazard, David Tavan, Kheir Eddine Benmammar, Brigitte Monange, Mohamed Ramdani, Denis Péré-Vergé, Floriane Huet-Penz, Ahmed Bedjaoui, Florent Genty, Cécile Leyronnas, Jérôme Busserolles, Sophie Trévis, Vincent Pinon, Denis Pezet, and David Balayssac. published: 04 November 2021 doi: 10.3389/fphar.2021.744085

Cross-Sectional Study of Prevalence, Characterization and Impact of Chronic Pain Disorders in Workers

Nicolas Kerckhove, Céline Lambert, Alice Corteval, Bruno Pereira, Alain Eschalier, Christian Dualé, 2020 Dec 10;S1526-5900(20)30107-3. doi: 10.1016/j.jpain.2020.11.005.

Long-Term Prevalence of Sensory Chemotherapy-Induced Peripheral Neuropathy for 5 Years after Adjuvant FOLFOX Chemotherapy to Treat Colorectal Cancer: A Multicenter Cross-Sectional Study

Selvy M, Pereira B, Kerckhove N, Gonneau C, Feydel G, Pétorin C, Vimal-Baguet A, Melnikov S, Kullab S, Hebbar M, Bouché O, Slimano F, Bourgeois V, Lebrun-Ly V, Thuillier F, Mazard T, Tavan D, Benmammar KE, Monange B, Ramdani M, Péré-Vergé D, Huet-Penz F, Bedjaoui A, Genty F, Leyronnas C, Busserolles J, Trevis S, Pinon V, Pezet D, Balayssac D.J Clin Med. 2020 Jul 27;9(8):2400. doi: 10.3390/jcm9082400.PMID: 3272709

mTOR activation by constitutively active serotonin6 receptors as new paradigm in neuropathic pain and its treatment

Martin PY, Doly S, Hamieh AM, Chapuy E, Canale V, Drop M,Chaumont-Dubel S, Bantreil X, Lamaty F, Bojarski A, Zajdel P, Eschalier A, Marin P, Courteix C
Progress In Neurobiology. 2020 June5. doi: https://doi.org/10.1016/j.pneurobio.2020.101846

The safety of medications used to treat peripheral neuropathic pain, part 1 (antidepressants and antiepileptics): review of double-blind, placebo-controlled, randomized clinical trials

Selvy M, Cuménal M, Kerckhove N, Courteix C, Busserolles J, Balayssac D.
Expert Opin Drug Saf. 2020 May 2. doi: 10.1080/14740338.2020.1764934

Testosterone-androgen receptor: The steroid link inhibiting TRPM8-mediated cold sensitivity

Gkika D, Lolignier S, Grolez GP, Bavencoffe A, Shapovalov G, Gordienko D, Kondratskyi A, Meleine M, Prival L, Chapuy E, Etienne M, Eschalier A, Shuba Y, Skryma R, Busserolles J, Prevarskaya N.
FASEB J. 2020 Apr 11. doi: 10.1096/fj.201902270R.

Replacement of current opioid drugs focusing on MOR-related strategies

Busserolles J, Lolignier S, Kerckhove N, Bertin C, Authier N, Eschalier A.
Pharmacol Ther. 2020 Mar 9:107519. doi: 10.1016/j.pharmthera.2020.107519.

Paracetamol is a centrally acting analgesic using mechanisms located in the periaqueductal grey

Barrière D, Boumezbeur F, Dalmann R, Cadeddu R, Richard D, Pinguet J, Daulhac L, Sarret P, Whittingstall K, Keller M, Mériaux S, Eschalier A, Mallet C.
Br J Pharmacol. 2020 Apr;177(8):1773-1792. doi: 10.1111/bph.14934. Epub 2020 Jan 22.

Ethosuximide improves chronic pain-induced anxiety- and depression-like behaviors

Kerckhove N, Boudieu L, Ourties G, Bourdier J, Daulhac L, Eschalier A, Mallet C
Eur Neuropsychopharmacol. 2019 Dec;29 (12):1419-1432. doi: 10.1016/j.euroneuro.2019.10.012. Epub 2019 Nov 22.

Risk assessment of using off-label morphine sulfate in a population-based retrospective cohort of opioid-dependent patients

Bertin C, Delorme J, Riquelme M, Peyrière H, Brousse G, Eschalier A, Ardid D, Chenaf C, Authier N
Br J Clin Pharmacol. 2019 Aug 6. PMID: 31389036 DOI: 10.1111/bcp.14082

The Peptide ERα17p Is a GPER Inverse Agonist that Exerts Antiproliferative Effects in Breast Cancer Cells

Lappano R, Mallet C, Rizzuti B, Grande F, Galli GR, Byrne C, Broutin I, Boudieu L, Eschalier A, Jacquot Y, Maggiolini M.
Cells. 2019 Jun 14;8(6). pii: E590. doi: 10.3390/cells8060590.

Effectiveness assessment of riluzole in the prevention of oxaliplatin-induced peripheral neuropathy: RILUZOX-01: protocol of a randomised, parallel, controlled, double-blind and multicentre study by the UNICANCER-AFSOS Supportive Care intergroup

Kerckhove N, Busserolles J, Stanbury T, Pereira B, Plence V, Bonnetain F, Krakowski I, Eschalier A, Pezet D, Balayssac D
BMJ Open. 2019 Jun 9;9(6):e027770. PMID: 31182448 PMCID: PMC6561607 DOI: 10.1136/bmjopen-2018-027770

Cav3.2 calcium channel inhibition: a new target for colonic hypersensitivity associated with low-grade inflammation

Picard E, Carvalho FA, Agosti F, Bourinet E, Ardid D, Eschalier A, Daulhac L, Mallet C.
Br J Pharmacol. 2019 Feb 4. DOI : 10.1111/bph.14608. [Epub ahead of print] PMID:30714145

Prescription opioid analgesic use in France: Trends and impact on morbidity-mortality

Chenaf C, Kaboré JL, Delorme J, Pereira B, Mulliez A, Zenut M, Delage N, Ardid D, Eschalier A, Authier N.
Eur J Pain. 2019 Jan;23(1):124-134. doi: 10.1002/ejp.1291. Epub 2018 Aug 20.

Chemotherapy-induced peripheral neuropathy: Symptomatology and epidemiology

Kerckhove N, Collin A, Condé S, Chaleteix C, Pezet D, Balayssac D, Guastella V.
Bull Cancer. 2018 Nov;105(11):1020-1032 PMID: 30244980 DOI: 10.1016/j.bulcan.2018.07.009

Prevalence of chronic pain with or without neuropathic characteristics in France using the capture-recapture method: a population-based study

Chenaf C, Delorme J, Delage N, Ardid D, Eschalier A, Authier N.
Pain. 2018 Nov;159(11):2394-2402. DOI : 10.1097/j.pain.0000000000001347. PMID : 30028790

Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin

Poupon L, Lamoine S, Pereira V, Barriere DA, Lolignier S, Giraudet F, Aissouni Y, Meleine M, Prival L, Richard D, Kerckhove N, Authier N, Balayssac D, Eschalier A, Lazdunski M, Busserolles J.
Neuropharmacology. 2018 Sep 15;140:43-61. DOI : 10.1016/j.neuropharm.2018.07.026. Epub 2018 Jul 26. PMID:30056126

Efficacy and safety of a T-type calcium channel blocker in patients with neuropathic pain: A proof-of-concept, randomized, double-blind and controlled trial

Kerckhove N, Pereira B, Soriot-Thomas S, Alchaar H, Deleens R, Hieng V, Serra E, Lanteri-Minet M, Arcagni P, Picard P, Lefebvre-Kuntz D, Maindet C, Mick G, Balp L, Lucas C, Creach C, Letellier M, Martinez V, Navez M, Delbrouck D, Kuhn E, Piquet E, Bozzolo E, Brosse C, Lietar B, Marcaillou F, Hamdani A, Leroux-Bromberg N, Perier Y, Vergne-Salle P, Gov C, Delage N, Gillet D, Romettino S, Richard D, Mallet C, Bernard L, Lambert C, Dubray C, Duale C, Eschalier A.
Eur J Pain. 2018 Aug;22(7):1321-1330. doi: 10.1002/ejp.1221. Epub 2018 Apr 18.

Chronic Pain Opioid-Maintained Patients Receive Less Analgesic Opioid Prescriptions

Delorme J, Chenaf C, Bertin C, Riquelme M, Eschalier A, Ardid D, Authier N.
Front Psychiatry. 2018 Jul 23;9:335. DOI : 10.3389/fpsyt.2018.00335. eCollection 2018. PMID : 30083113

Assessment of the effectiveness and safety of ethosuximide in the treatment of abdominal pain related to irritable bowel syndrome - IBSET: protocol of a randomised, parallel, controlled, double-blind and multicentre trial

Kerckhove N, Scanzi J, Pereira B, Ardid D, Dapoigny M.
BMJ Open. 2017 Jul 18;7(7):e015380 PMID: 28720615 PMCID: PMC5734298 DOI: 10.1136/bmjopen-2016-015380

La recherche publique sur la douleur en France : état des lieux, propositions

Eschalier A.Douleur analg, 31 4 (2018) 205-211.
DOI: 10.3166/dea-2018-0036

La Lettre du Pharmacologue - Dossier Antalgiques

La Lettre du Pharmacologue - Rédigé par l'Institut ANALGESIA et l'OFMA
Vol.31 - n°4 - Oct.-nov.-déc. 2017

Misuse and dependence on prescription opioids: Prevention, identification and treatment.

Rolland B, Bouhassira D, Authier N, Auriacombe M, Martinez V, Polomeni P, Brousse G, Schwan R, Lack P, Bachellier J, Rostaing S, Bendimerad P, Vergne-Salle P, Dematteis M, Perrot S.
Rev Med Interne. 2017 Aug;38(8):539-546. doi: 10.1016/j.revmed.2016.12.024. Epub 2017 Feb 15.

Clinical assessment of new antineuropathic strategies for chemotherapy-induced peripheral neuropathy: pain should not be the principal endpoint

Kerckhove N, Pereira B, Pezet D, Balayssac D.
Pain. 2017 PMID: 27984530 DOI: 10.1097/j.pain.0000000000000743

Long-Term Effects, Pathophysiological Mechanisms, and Risk Factors of Chemotherapy-Induced Peripheral Neuropathies: A Comprehensive Literature Review

Kerckhove N, Collin A, Condé S, Chaleteix C, Pezet D, Balayssac D.
Front Pharmacol. 2017 Feb 24;8:86 PMID: 28286483 PMCID: PMC5323411 DOI: 10.3389/fphar.2017.00086

Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence

Chenaf C, Chapuy E, Libert F, Marchand F, Courteix C, Bertrand M, Gabriel C, Mocaër E, Eschalier A, Authier N.
Pain. 2017 Jan;158(1):149-160. PMID : 27984527

Codeine Shopping Behavior in a Retrospective Cohort of Chronic Noncancer Pain Patients: Incidence and Risk Factors

Chenaf C, Kabore JL, Delorme J, Pereira B, Mulliez A, Roche L, Eschalier A, Delage N, Authier N.
J Pain. 2016 Dec;17(12):1291-1301 PMID: 27592608 DOI: 10.1016/j.jpain.2016.08.010

Trend in buprenorphine and methadone shopping behavior in France from 2004 to 2014

Kernisant M, Delorme J, Kabore JL, Brousse G, Laporte C, Zenut M, Chenaf C, Authier N.
Presse Med. 2016 Dec;45(12 Pt 1):e369-e375. DOI : 10.1016/j.lpm.2016.10.011. Epub 2016 Nov 4. French. PMID : 27823911

Assessment of the effectiveness and safety of Ethosuximide in the Treatment of non-Diabetic Peripheral Neuropathic Pain: EDONOT-protocol of a randomised, parallel, controlled, double-blinded and multicentre clinical trial

Kerckhove N, Mallet C, Pereira B, Chenaf C, Duale C, Dubray C, Eschalier A.
BMJ Open. 2016 Dec 16;6(12):e013530. doi: 10.1136/bmjopen-2016-013530.

Incidence of tramadol shopping behavior in a retrospective cohort of chronic non-cancer pain patients in France

Chenaf C, Kabore JL, Delorme J, Pereira B, Mulliez A, Roche L, Eschalier A, Delage N, Authier N.
Pharmacoepidemiol Drug Saf. 2016 Sep;25(9):1088-98. DOI : 10.1002/pds.4056. Epub 2016 Jun 30. PMID : 27363310

Incidence of high dosage buprenorphine and methadone shopping behavior in a retrospective cohort of opioid-maintained patients in France

Delorme J, Chenaf C, Kabore JL, Pereira B, Mulliez A, Tremey A, Brousse G, Zenut M, Laporte C, Authier N.
Drug Alcohol Depend. 2016 May 1;162:99-106. PMID: 27006272 DOI: 10.1016/j.drugalcdep.2016.02.035

Cholinergic Neurotransmission in the Posterior Insular Cortex Is Altered in Preclinical Models of Neuropathic Pain: Key Role of Muscarinic M2 Receptors in Donepezil-Induced Antinociception

Ferrier J, Bayet-Robert M, Dalmann R, El Guerrab A, Aissouni Y, Graveron-Demilly D, Chalus M, Pinguet J, Eschalier A, Richard D, Daulhac L, Marchand F, Balayssac D.
J Neurosci. 2015 Dec 16;35(50):16418-30. DOI : 10.1523/JNEUROSCI.1537-15.2015. PMID : 26674867